Expression of Urokinase-Type Plasminogen Activator and Its Receptor during Ovarian Follicular Development
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چکیده
منابع مشابه
Expression of urokinase-type plasminogen activator and its receptor is up-regulated during tendon healing.
The urokinase-type plasminogen activator (uPA) system has been implicated in cell migration, angiogenesis, extracellular matrix synthesis and tissue remodelling. However, little is known about the role of the system in tendon healing. We used a rat Achilles tendon model to study mRNA and protein expression of uPA and its receptor (uPAR) during tendon healing using immunohistochemical, Northern ...
متن کاملExpression of urokinase plasminogen activator and plasminogen activator inhibitor type-1 in ovarian cancer and its clinical significance.
The urokinase plasminogen activator system, which consists of urokinase plasminogen activator (uPA), plasminogen activator inhibitor type-1 (PAI-1) and urokinase plasminogen activator receptor (uPAR), plays an important role in tumor invasion and metastasis, and it may be a potential diagnostic biomarker and therapeutic target in cancer. It has be...
متن کاملExpression of urokinase-type plasminogen activator, its receptor, and its inhibitor in gastric adenocarcinoma tissues.
The plasminogen and plasmin system, which is mainly regulated by urokinase-type plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1), is generally believed to play a role in cancer invasion and metastasis. This study was conducted to investigate the role of uPA, uPAR and PAI-1 in the invasion and metastasis of gastric adenocarcinoma. The expression of mRNAs for uPA and PAI...
متن کاملUrokinase type plasminogen activator receptor expression in colorectal neoplasms.
BACKGROUND The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis. AIMS To study the involvement of uPAR in colorectal carcinogenesis. METHODS The cellular expression and localisation of uPAR were investigated in colorectal adenomas and invasive carcinomas by in situ hybridisation, immunohistochemistry, and northern and western bl...
متن کاملExpression of urokinase-type plasminogen activator and its receptor in keloids.
BACKGROUND The urokinase-mediated plasminogen activation (uPA) system plays a central role in a number of cellular processes including tissue remodeling, cell migration, and angiogenesis. Elevated uPA activity has also been seen with tumor invasion and metastasis in a variety of malignancies. Keloids represent an aberrant form of wound healing characterized by uncontrolled growth with invasion ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1997
ISSN: 0013-7227
DOI: 10.1210/en.138.7.2790